Oxidative Stress and Male Fertility

Essentially, Oxidative stress is an imbalance between the production of oxidants (also called free radicals), and the ability of the body to counteract harmful effects through neutralization by antioxidants. Prolonged oxidative stress can damage and lead to death of cells. And this can act as a significant factor of male infertility.

Oxidants or oxidizing agents are by-products generated through several reactions within our body. In sperm, oxidants may lead to protein damage, lipid peroxidation (destruction of lipids), apoptosis (controlled cell death) and DNA damage weakening its fertilization potential,

Immunity Shield to Free Radicals

Antioxidants describe a broad category of substances, which can inhibit oxidation and protect our bodies against the damaging effects of oxidants. Their role is to neutralize oxidants, maintaining the required balance within the cells, to protect them from getting injured (and possibly leading to male infertility).

Oxidative Stree

The list of antioxidants is long. Accordingly, it can be divided into those that are:

  • produced naturally in our bodies (e.g. glutathione, catalase)
  • present in food called dietary antioxidants (vitamins, minerals, carotenoids, polyphenols, etc.).

Is Oxidative Stress Affecting Human sperm?

While low production of oxidative stress is necessary for normal physiological function, excessive production disrupts the balance between oxidants and antioxidants and brings a number of pathological defects. These defects have been directly associated with impaired sperm function.

Thus, oxidants react with the bio-molecules that compose the sperm cells (lipids, proteins, nucleic acids, sugars). Damage to the lipids, proteins and sugars may inactivate or cause the death of sperm cells. This is while DNA damage is correlated with poor fertilization rate, high frequency of miscarriage and morbidity in the offspring.


Sperms are vulnerable to oxidation because their membranes contain large amounts of unsaturated fatty acids, a certain category of fatty acids that are very sensitive to oxidation.. Moreover, spermatozoa have limited repair mechanisms against the damage caused by free radicals since they do not have the building blocks to produce new material.

Practice to protect sperm cells

Studies have highlighted that nutrition and supplementation as playing a key role in counteracting the harmful effects on sperm. Especially vitamins and minerals have been found to be vital for the protection against oxidative stress .

Therefore, treatment with antioxidants may increase sperm parameters such as sperm count, sperm motility, and sperm morphology. The biggest source of natural antioxidants are fruits and vegetables. We highly recommend you consume a high amount of fruits such as berries and vegetables such as leafy greens, cruciferous vegetables and tomatoes.

Furthermore, nother essential route of getting the oxidants is physical activity. Exercising for 45 minutes 3 times per week has been shown to decrease the oxidative stress of the seminal fluid. We therefore highly recommend that you do some sort of physical activity. If you want to know more, have a look at our blog post on how to improve male fertility with exercise

Moreover, it is highly advised to minimize the exposure to lifestyle factors, such as smoking, alcohol consumption, exposure to heat, radiation and other pollutants. These increase oxidative stress and, in turn, lead to sperm damage, decreasing your fertility status.

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